Most
of my readers know that, a year ago, I was diagnosed with
severe ulcerative colitis, a chronic inflammatory bowel
disease. The
disease has no known cause or cure, and flares up irregularly, usually
provoked by stress. It is one of a large group of chronic diseases,
including arthritis, diabetes, lupus, endometriosis, MS, chronic
fatigue syndrome, asthma, allergies, and Crohn's disease, all of which
are manifested by recurrent hyperactivity of the immune system, usually
producing cell or tissue death and related inflammation, as a
'storm'
of cytokine messenger proteins urges the body's T- and B- immune cells
to run somewhat amok in an over-response or mis-response to a
perceived
threat. [Cytokine 'storms', interestingly, are also apparently
produced
by pandemic influenza (both human and poultry forms).]
The treatment for the symptoms of ulcerative
colitis generally
entails high doses of steroidal or non-steroidal anti-inflammatory
drugs. More recent treatments include probiotics (live bacteria
ingested to replace the deficient ones in the gut), prebiotics
(oligosaccharide carbohydrates that encourage growth of gut bacteria
a.k.a. 'colonic flora'), omega-3 (inhibits the
body's production of
leukotrienes and prostaglandins implicated in inflammation), and drugs
that attempt, clumsily, to regulate the immune system's
(over-)response.
There is some compelling (but, alas, not
irrefutable) evidence
that this family of diseases, many of them nearing epidemic levels in
affluent nations, are caused by chronic exposure to a combination
of environmental toxins in our air, water, soil and
food. The newest
theory implicates the body's reaction to oxidants contained in
preservatives, oils, gasoline, plastics, cosmetics and a host of other
man-made products and wastes. This 'oxidative stress' is exacerbated by
strenuous exercise. This is paradoxic because exercise is the principal
means by which sufferers of these diseases manage
the emotional stress
in their lives, and because these diseases are
catalyzed (
i.e. flare-ups brought on) by chronic high levels of emotional
stress.
Since our society is incapable and unwilling to deal
with
environmental toxins (part of what I ranted about in
Monday's post),
sufferers must attempt to mitigate the stress in their lives, to reduce
the need for their immune system to go into action (and hence, often,
overreaction). Easier said than done.
My quote from Varela's work in my post last Sunday has
got me thinking
about how the immune system 'works' and how it might be malfunctioning
in the
skyrocketing number of immune system hyperactivity disease sufferers.
His point is that the immune 'system' is actually a combination
of:
- a relatively simple, mechanistic system (called
clonal selection, illustrated at right, by which stem cells form into
lymphocytes ready to respond to many types of antigens, and then, when
they actually encounter antigens, neutralize them and clone themselves
to be
ready for reinfection by the same antigen), and
- a more complex, dynamic network (a learning,
evolving, self-regulating network
with the intelligence
to, as Varela puts it, "know and select what it
should pay attention to")
He calls this a 'second generation network', but there
should be a name for a combination of a system and a network,
integrated together. Since there isn't one, I'm coining one: a setwork. This is
what millions of years of evolution has produced in our
bodies, and it makes sense for the same reasons that we have both a
system
that acts without thinking (instinct) and a network
that learns what to
pay attention to (intelligence) in our brains -- our mental setwork. The
two work better than
either would work alone.
Now, as Stewart & Cohen explain in Figments
of Reality, we are " a complicity
of the separately-evolved creatures in our bodies organized for
their
mutual benefit i.e. we are an organism. And our brains, our
intelligence, awareness, consciousness and free-will, are nothing more
than an evolved, shared, feature-detection system jointly developed to
advise these creatures' actions for their mutual
benefit. Our
brains, and our minds (the processes that our neurons, senses and
motility organs carry out collectively) are their
information-processing system, not 'ours'."
I think it is enormously helpful, in order to 'get outside yourself'
and see the purpose of setworks, to appreciate that you're not 'you', but
merely a reflection of their
(the organs in a bag of water that you call your body) evolving
survival setworks.
If the purpose of these setworks (mental and immunological) is to
protect 'you' (in the interests of 'their' survival) the next question
is: from what?
Valera's and
his colleagues' answer would appear to be, 'others', 'not-them', based
on an evolving collective understanding of who 'they' are. This is
heavy stuff, but it follows logically from an understanding that
setworks, by their nature, have intelligence, and therefore are capable
of such understanding (recent studies suggest the immunological setwork
is at least as intricate and complex as the mental one). That
understanding of 'other-ness' informs them, as Varela says "what to pay
attention to". In a very real sense, then, our bodies, through the
immunological setwork, have evolved a culture
-- a code of behaviours that are, and are not, acceptable, the
contravention of which is dealt with harshly. This is a culture that we
are not even conscious of (because consciousness is part of the other,
mental setwork).
Darwinian principles would suggest that this body culture's 'reasoning'
(these are strange words to use in this context, eh?) is driven by
interests of survival -- if it weren't, it wouldn't have survived and
we (and 'they') wouldn't be around to debate the issue. So then we have
to ask: Whose survival?
Is it
the survival of each individual organ (driven by selfishness), or the
survival of the whole organism that is 'their' body (altruistic
survival)? The answer to this, intuitively, is the same as it is in the
culture we are more familiar with (our social culture) -- there is a
constant tension between both. The interests of both must be balanced,
because they are co-dependent. When there is a strong conflict between
these interests, it will ultimately be resolved in favour of the
survival of the whole. I suspect that the immunological setwork has
'learned' and 'knows' this and acts accordingly (again, because if it
didn't we'd be extinct).
This got me thinking about Gaia (as organism of all-life-on-Earth).
"Nature always bats last", so just as in 'our' bodies, serious
conflicts between the culture/interests of the whole organism and the
culture/interests of its component 'organs' will ultimately be resolved
in favour of the greater whole. Is
Gaia, then, the immunological setwork of Earth?
So what happens when there is a breakdown in these self-regulatory
setworks, when selfish behaviour of constituent organs overpowers the
interests of the collective organism? We see this in cancers, in immune
system failures, and (I would argue) in civilizations.
The answer to this is obvious and exciting: Such breakdowns are
inherently self-defeating and unsustainable. They will ultimately fail.
So why do they occur at all? Why after millions of years of painstaking
evolution would these costly errors still occur? The answer: They occur deliberately. Setworks
learn by trying lots of slightly different experiments to see what
works a bit better, and what doesn't work. This is what evolution is
all about. Cancers, immune diseases and civilizations are all learning
experiments reacting to stresses that must either be adapted to (if
possible) or defeated (if not). What doesn't kill us makes us stronger.
These diseases are our setworks' fire drills, practices in seeing 'what
if' the organism adapted this way, or this way, or maybe this
way. The types of stresses our bodies are used to adapting to are
things like being chased by cougars. We developed 'fight or flight'
responses to such stresses because they worked. Those without them got
eaten. Those with them survived and passed them on. Our bodies, I would
suggest, are furiously trying things out to see what adaptation might
cope with these new environmental stresses: the massive, ubiquitous
antibiotics and industrial chemicals we ingest constantly. They're
trying to evolve our bodies so that, no matter how much of these
poisons we ingest, our setworks will have a way of dealing with them
that will keep the organism healthy.
The problem, of course, is timing. We had millions of years to learn to
cope with the stresses of hungry predators (and we have adapted
wonderfully to them). But we've only had a few hundred, at most a few
thousand, years to learn to cope with the modern stresses. The cancers
and immune diseases (and perhaps mental illnesses) we get are clearly
not the best adaptations, though we won't know whether they're on the
right track or not until we've had a few million years to let them, and
other experiments, evolve. That is the natural pace of things.
Unfortunately, we don't have
a
few million years. These changes are happening way too fast. And when
environmental changes occur faster than setworks' ability to adapt to
them, the result is called Extinction.
Perhaps Gaia will learn from the mistake of "letting the apes run the
laboratory for awhile". Perhaps the next evolution, after our
extinction, will be a creature with a smaller brain, or at least
without an opposable thumb, one that will evolve 'culturally' at a pace
that its physical evolution can keep pace with. Almost assuredly, this
next invention will have a much greater tolerance for chemicals and
antibiotics than our maladjusted bodies. Perhaps, before we disappear,
we will start to see some signs of what that next invention will be.
Or perhaps it's already here, flying or buzzing around us, and we're
just too preoccupied with current stresses to recognize it.
Image: Clonal
selection, the mechanistic, system component of immunity, from Wikipedia
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1:20:45 AM
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