Clint Eastwood (Unforgiven, Mystic River and Million Dollar Baby), could become one of the most winningest directors in history if he wins for his World War II epic Flags of Our Fathers. (John Ford won four awards. Frank Capra and William Wyler both received three each.)
Jack Nicholson, in a highly-acclaimed performance as a crime boss in The Departed, could tie Katherine Hepburn for the most acting Oscars won (4).
Seven-time loser Peter O'Toole could finally win an Oscar for his performance in Venus.
Five-time loser Martin Scorsese (Raging Bull, The Last Temptation of Christ, GoodFellas, Gangs of New York, and The Aviator) could finally win his first Oscar with his critically-acclaimed Boston mob film The Departed.
Spain’s Pedro Almadovor could win his fourth Foreign Film Oscar for Volver, starring Penelope Cruz, who could wind up receiving her first Best Actress nomination.